Hydroxychloroquine does not reduce deaths from COVID-19, and probably does not reduce the number of people needing mechanical ventilation, state the authors of a new Cochrane Review. In addition, they note that no new trials of hydroxychloroquine or chloroquine for treating COVID-19 should be started.

What are the benefits and risks of atovaquone‐proguanil for treating uncomplicated malaria caused by the Plasmodium falciparum parasite?What is the aim of this review?

How accurate are tests (Xpert Ultra and Xpert MTB/RIF) for diagnosing tuberculosis outside the lungs (extrapulmonary tuberculosis) and rifampicin resistance?Why is using Xpert tests for extrapulmonary tuberculosis important?

Two updated Cochrane reviews and one new protocol are available in Issue 1, 2021 of the Cochrane Database of Systematic Reviews. 

One new and one updated Cochrane review are available in Issue 12 of the Cochrane Database of Systematic Reviews. 

Treating uncomplicated malaria in children: do child‐friendly formulations of medicines work better than usual tablet formulations?What is the aim of this review?

Update: Probiotics for treating acute infectious diarrhoea

One new COVID-19 review, one new Cochrane review  and one updated COVID-19 review  are available in Issue 11 of the Cochrane Database of Systematic Reviews.