Xpert MTB/RIF and Xpert Ultra for diagnosing pulmonary tuberculosis and rifampicin resistance in adults

Most Cochrane Reviews look at the effects of interventions on health, but a growing number provide evidence on how to diagnose a disease. In June 2019, one of these, on a test used to detect tuberculosis, was updated. The lead author, David Horne from the University of Washington in Seattle in the USA, sets the scene and tells us what the review found.

Horne  DJ, Kohli  M, Zifodya  JS, Schiller  I, Dendukuri  N, Tollefson  D, Schumacher  SG, Ochodo  EA, Pai  M, Steingart  KR

Podcast Published October 2019 

Effects of starting antiretroviral therapy within one week of diagnosis on people living with HIV 

Among the dozens of Cochrane Reviews of various treatments for people with HIV or AIDS, are some that look more at how the treatments should be used, rather than the treatments themselves. One of these examines the timing of the start of treatment, and it was published in June 2019. Lead author, Alberto Mateo from the Liverpool School of Tropical Medicine in the UK, tells us about the evidence base and the findings for this important question.

Mateo‐Urdiales  A, Johnson  S, Smith  R, Nachega  JB, Eshun‐Wilson  I

Podcast published September 2019

Vaccines for preventing rotavirus diarrhoea: vaccines in use 

Rotavirus infection is a common cause of diarrhea and a variety of vaccines are used to try to prevent it. The evidence for these is examined in the fourth update of a Cochrane Review, published in March 2019 . Hanna Bergman one of the authors based in the Cochrane Response team in London UK tells us  about the problem and the latest findings.

Soares‐Weiser  K, Bergman  H, Henschke  N, Pitan  F, Cunliffe  N

Podcast published May 2019

Xpert® MTB/RIF  assay for extrapulmonary tuberculosis and rifampicin resistance 

Most Cochrane Reviews look at the effects of interventions on health, but a growing number are providing evidence on the accuracy of different ways of diagnosing a disease. These were added to in August 2018 by a new review on a test used in the management of tuberculosis. The review's first author, Mikashmi Kohli from McGill University in Montreal Canada, sets the scene and tells us what they found in this podcast.

Kohli M, Schiller I, Dendukuri N, Dheda k, Denkinger CM, Schumacher SG, Steingart KR

Podcast published October 2018

The accuracy of rapid diagnostic tests  for detecting typhoid and paratyphoid (enteric) fever

Point-of-care rapid diagnostic tests which use a small amount of blood are available for infectious diseases such as malaria and HIV, and make an important contribution to patient management. Cochrane reviews of the accuracy of such tests have influenced WHO policy and, in May 2017, they were added to with a new Cochrane Diagnostic Test Accuracy review of rapid tests for typhoid and paratyphoid fevers. Lalith Wijedoru from the Alder Hey Children's Hospital in Liverpool in UK tells us more in this podcast.

Wijedoru L, Mallett S, Parry CM

Podcast published October 2017

School-based interventions for preventing HIV, sexually transmitted infections,and pregnancy in adolescents

Mason-Jones AJ, Sinclair D, Mathews C, Kagee A, Hillman A, Lombard C

Podcast published March 2017

3ie London Evidence Week, April 2016

3ie interviewed Professor Paul Garner, Liverpool School of Tropical Medicine and Coordinating Editor, Cochrane Infectious Diseases Group on the relevance of systematic reviews and evidence gap maps in policymaking

Directly observed therapy for treating tuberculosis

Jamlick Karumbi, Paul Garner 

Published 23 July 2015

Intermittent preventive antimalarial treatment for children with anaemia

Anke Rohwer, based at the Centre for Evidence-based Health Care at Stellenbosch University in South Africa, describes the rationale and findings in this Evidence Podcast.

Published 20 April  2015


Drugs for treating urinary schistosomiasis 

Kramer CV, Zhang F, Sinclair D, Olliaro P

Published 6 August 2014


 LSTM Podcast April 2013

Paul Garner - Systematic reviews, Cochrane and international development

Xpert® MTB/RIF test for diagnosing pulmonary tuberculosis and rifampicin resistance in adults

Steingart KR, Schiller I, Horne DJ, Pai M, Boehme CC, Dendukuri N

Published 1 January 2013


Deworming drugs for treating soil-transmitted intestinal worms in children: effects on nutrition and school performance 

Taylor-Robinson DC, Maayan N, Soares-Weiser K, Donegan S, Garner P

Published 14 November 2012


Vaccines for preventing rotavirus diarrhoea: vaccines in use 

Soares-Weiser K, MacLehose H, Bergman H, Ben-Aharon I, Nagpal S, Goldberg E, Pitan F, Cunliffe N

Published 14 November 2012


Rapid diagnostic tests for diagnosing uncomplicated P. falciparum malaria in endemic countries

Abba  K, Deeks  JJ, Olliaro  PL, Naing  CM, Jackson  SM, Takwoingi  Y, Donegan  S, Garner  P.

Published 06 July 2011


Probiotics for treating acute infectious diarrhoea

Allen SJ, Martinez EG, Gregorio GV, Dans LF

Published 8 December 2010